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ERLIN2 Polyklonaler Antikörper

ERLIN2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14781-1-PBS

Synonyme

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  • Western Blot (WB) analysis of HeLa cells using ERLIN2 Polyclonal antibody (14781-1-AP)

    WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 14781-1-AP (ERLIN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using ERLIN2 Polyclonal antibody (14781-1-AP)

    WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 14781-1-AP (ERLIN2 antibody) at dilution of 1:100 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human liver cancer tissue using ERLIN2 Polyclonal antibody (14781-1-AP)

    IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human liver cancer tissue using ERLIN2 Polyclonal antibody (14781-1-AP)

    IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

14781-1-PBS bindet in WB, IHC, Indirect ELISA ERLIN2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ERLIN2 fusion protein Ag6369
Vollständiger Name ER lipid raft associated 2
Berechnetes Molekulargewicht 38 kDa
Beobachtetes Molekulargewicht 38-45 kDa
GenBank-ZugangsnummerBC067765
Gene symbol ERLIN2
Gene ID (NCBI) 11160
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.