ESCO2 Polyklonaler Antikörper

ESCO2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 23525-1-PBS

Synonyme

N acetyltransferase ESCO2, hEFO2, Establishment factor-like protein 2, EFO2p, EFO2

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  WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23525-1-AP (ESCO2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23525-1-AP (ESCO2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

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  IHC staining of human skin cancer using 23525-1-AP (same clone as 23525-1-PBS)

  Immunohistochemical analysis of paraffin-embedded skin cancer slide using 23525-1-AP (ESCO2 antibody) at dilution of 1:300 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

23525-1-PBS bindet in WB, IHC, Indirect ELISA ESCO2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: ESCO2 fusion protein Ag18893
• Vollständiger Name: establishment of cohesion 1 homolog 2 (S. cerevisiae)
• Berechnetes Molekulargewicht: 601 aa, 68 kDa
• Beobachtetes Molekulargewicht: 65-70 kDa
• GenBank-Zugangsnummer: BC146562
• Gene symbol: ESCO2
• Gene ID (NCBI): 157570
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-affinitätsgereinigt
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ESCO2 is also known as Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2, EFO2. This gene encodes a member of the family of acetyltransferases involved in the establishment of sister chromatid cohesion during S phase and postreplicative sister chromatid cohesion induced by double-strand breaks (PubMed: 15821733). Mutations in the ESCO2 gene are associated with a rare genetic disorder called Roberts syndrome or SC phocomelia syndrome (PubMed: 16380922). The loss of function or impaired activity of the ESCO2 protein due to mutations disrupts the proper cohesion of sister chromatids, leading to chromosomal abnormalities and the characteristic features of Roberts syndrome. ESCO2 can be detected as about 65-70 kDa.