ESM1 Rekombinanter Antikörper

ESM1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250287H3

Kat-Nr. : 86027-1-PBS

Synonyme

endocan, endothelial cell molecule 1, Endothelial cell specific molecule 1, Endothelial cell-specific molecule 1, ESM-1

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  WB analysis using 86027-1-RR (same clone as 86027-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86027-1-RR (ESM1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86027-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86027-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86027-1-RR against Human ESM1 were performed. The affinity constant is 66.5 nM.

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Geprüfte Anwendungen

Produktinformation

86027-1-PBS bindet in WB, Indirect ELISA ESM1 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: ESM1 fusion protein Ag3019
• Vollständiger Name: endothelial cell-specific molecule 1
• Berechnetes Molekulargewicht: 184 aa, 20 kDa
• Beobachtetes Molekulargewicht: 14 kDa
• GenBank-Zugangsnummer: BC011989
• Gene symbol: ESM1
• Gene ID (NCBI): 11082
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ESM1, also known as endocan or endothelial cell-specific molecule 1, is a protein-coding gene that encodes a secreted proteoglycan primarily expressed in endothelial cells of human tissues, including lung, kidney, and vascular systems. The protein consists of a 20 kDa core protein with a dermatan sulfate chain, forming a 50 kDa mature proteoglycan. ESM1 plays a crucial role in endothelial cell proliferation, migration, and angiogenesis (blood vessel formation). It modulates vascular development and maintains endothelial homeostasis. Overexpression of ESM1 is observed in cancers such as gastric, cervical, and lung tumors, where it promotes angiogenesis and tumor progression via pathways like VEGF/ERK signaling. Elevated serum ESM1 levels are associated with poor clinical outcomes in cancer patients.