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EXD2 Rekombinanter Antikörper

EXD2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250133E4

Kat-Nr. : 85832-4-PBS

Synonyme

3'-5' exoribonuclease EXD2, C14orf114, EC:3.1.11.1, EC:3.1.13.-, EXDL2

Filter:
  • Western Blot (WB) analysis of various lysates using EXD2 Recombinant antibody (85832-4-RR)

    WB analysis using 85832-4-RR (same clone as 85832-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85832-4-RR (EXD2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85832-4-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using EXD2 Recombinant antibody (85832-4-RR)

    WB analysis using 85832-4-RR (same clone as 85832-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85832-4-RR (EXD2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85832-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85832-4-PBS bindet in WB, Indirect ELISA EXD2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen EXD2 fusion protein Ag14090
Vollständiger Name exonuclease 3'-5' domain containing 2
Berechnetes Molekulargewicht 70 kD aa, 56 kDa
Beobachtetes Molekulargewicht56 kDa, 70 kDa
GenBank-ZugangsnummerBC001962
Gene symbol EXD2
Gene ID (NCBI) 55218
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

EXD2 (Exonuclease 3'-5' Domain Containing 2), is a protein with exonuclease activity of 3'-5' nucleic acid, which is involved in many biological processes in cells, including DNA repair, RNA processing and mitochondrial translation. EXD2 protein is mainly located in mitochondrial outer membrane, intermediate fiber cytoskeleton and DNA damage site. This protein may be a potential drug target in some cancers. For example, in ALT (telomere selective elongation) dependent cancer, the co-elimination of EXD2 with BLM, DNA2 or POLD3 may mediate synthetic lethality. In addition, EXD2 inhibitors may exert anticancer effects by inhibiting mitochondrial translation and metabolic reprogramming. It has two isoforms with molecular weights of 56 kDa and 70 kDa respectively.