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EXOSC10 Polyklonaler Antikörper

EXOSC10 Polyklonal Antikörper für WB, IHC, IF/ICC, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, IF/ICC, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11178-1-PBS

Synonyme

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  • Western Blot (WB) analysis of HeLa cells using EXOSC10 Polyclonal antibody (11178-1-AP)

    WB analysis of HeLa using 11178-1-AP (same clone as 11178-1-PBS)

    WB result of EXOSC10 antibody (11178-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-EXOSC10 transfected HeLa cells. This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of MCF-7 cells using EXOSC10 Polyclonal antibody (11178-1-AP)

    IP experiment of MCF-7 using 11178-1-AP (same clone as 11178-1-PBS)

    IP result of anti-EXOSC10 (IP:11178-1-AP, 4ug; Detection:11178-1-AP 1:300) with MCF-7 cells lysate 3200 ug. This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using EXOSC10 Polyclonal antibody (11178-1-AP)

    IHC staining of human breast cancer using 11178-1-AP (same clone as 11178-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer using 11178-1-AP (EXOSC10 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of NIH/3T3 cells using EXOSC10 Polyclonal antibody (11178-1-AP)

    IF Staining of NIH/3T3 using 11178-1-AP (same clone as 11178-1-PBS)

    Immunofluorescent analysis of NIH/3T3 cells using 11178-1-AP (EXOSC10 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

11178-1-PBS bindet in WB, IHC, IF/ICC, IP, Indirect ELISA EXOSC10 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen EXOSC10 fusion protein Ag1666
Vollständiger Name exosome component 10
Berechnetes Molekulargewicht 98 kDa
Beobachtetes Molekulargewicht100 kDa
GenBank-ZugangsnummerBC039901
Gene symbol EXOSC10
Gene ID (NCBI) 5394
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a neuclear
ucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl 2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl paitents. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.