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EXOSC6 Polyklonaler Antikörper

EXOSC6 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30685-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using EXOSC6 Polyclonal antibody (30685-1-AP)

    WB analysis using 30685-1-AP (same clone as 30685-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30685-1-AP (EXOSC6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30685-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30685-1-PBS bindet in WB, Indirect ELISA EXOSC6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen EXOSC6 fusion protein Ag33513
Vollständiger Name exosome component 6
Berechnetes Molekulargewicht28kd
Beobachtetes Molekulargewicht28-32 kDa
GenBank-ZugangsnummerNM_058219
Gene symbol EXOSC6
Gene ID (NCBI) 118460
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

EXOSC6 (exosome component 6), also known as p11 or MTR3. The calculated molecular weight of EXOSC6 is 28 kDa. And it has low tissue specificity. The gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. It is also a component of the RNA exosome complex (PMID: 29906447). The composition of human exosome is similar to its yeast counterpart. EXOSC6 is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.