• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

EXOSC6 Rekombinanter Antikörper

EXOSC6 Rekombinant Antikörper für IF/ICC, Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241535G9

Kat-Nr. : 84346-2-PBS

Synonyme

MTR3, hMtr3p, hMtr3, exosome component 6, EAP4

Filter:
  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using EXOSC6 Recombinant antibody (84346-2-RR)

    IF Staining of HeLa using 84346-2-RR (same clone as 84346-2-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using EXOSC6 antibody (84346-2-RR, Clone: 241535G9 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84346-2-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP01222-1

    Cytometric bead array standard curve of MP01222-1

    Cytometric bead array standard curve of MP01222-1, EXOSC6 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84346-2-PBS. Detection antibody: 84346-1-PBS. Standard: Ag33513. Range: 0.781-100 ng/mL.

  • Affinity and Kinetic Characterization of 84346-2-RR

    Affinity and Kinetic Characterization of 84346-2-RR

    Biolayer interferometry (BLl) kinetic assays of 84346-2-RR against Human EXOSC6 were performed. The affinity constant is 0.399 nM.

Geprüfte Anwendungen

Produktinformation

84346-2-PBS bindet in IF/ICC, Cytometric bead array, Indirect ELISA EXOSC6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen EXOSC6 fusion protein Ag33513
Vollständiger Name exosome component 6
Berechnetes Molekulargewicht28kd
Beobachtetes Molekulargewicht28-32 kDa
GenBank-ZugangsnummerNM_058219
Gene symbol EXOSC6
Gene ID (NCBI) 118460
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

EXOSC6 (exosome component 6), also known as p11 or MTR3. The calculated molecular weight of EXOSC6 is 28 kDa. And it has low tissue specificity. The gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. It is also a component of the RNA exosome complex (PMID: 29906447). The composition of human exosome is similar to its yeast counterpart. EXOSC6 is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.