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EXTL3 Polyklonaler Antikörper

EXTL3 Polyklonal Antikörper für IP, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

IP, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10588-1-PBS

Synonyme

EC:2.4.1.223, Exostosin-like 3, EXTL1L, EXTR1, EXT-related protein 1

Filter:
  • Immunoprecipitation (IP) experiment of mouse pancreas tissue using EXTL3 Polyclonal antibody (10588-1-AP)

    IP experiment of mouse pancreas using 10588-1-AP (same clone as 10588-1-PBS)

    IP result of anti-EXTL3 (IP:10588-1-AP, 4ug; Detection:10588-1-AP 1:1000) with mouse pancreas tissue lysate 3200 ug. This data was developed using the same antibody clone with 10588-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of HEK-293T cells using EXTL3 Polyclonal antibody (10588-1-AP)

    IP experiment of HEK-293T using 10588-1-AP (same clone as 10588-1-PBS)

    IP result of anti-EXTL3 (IP:10588-1-AP, 4ug; Detection:10588-1-AP 1:1000) with HEK-293T cells lysate 1840 ug. This data was developed using the same antibody clone with 10588-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

10588-1-PBS bindet in IP, ELISA EXTL3 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen EXTL3 fusion protein Ag0936
Vollständiger Name exostoses (multiple)-like 3
Berechnetes Molekulargewicht 105 kDa
Beobachtetes Molekulargewicht105 kDa
GenBank-ZugangsnummerBC006363
Gene symbol EXTL3
Gene ID (NCBI) 2137
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Exostosin like glycosyltransferase 3 (EXTL3), also known as RPR, is located at chromosome 8p21.1 and composed of 919 amino acids, making it the longest member of the EXT family (PMID: 35676258). EXTL3 encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS) (PMID: 24128412). EXTL3 has been identified as a receptor molecule for regenerating islet-derived (REG) protein ligands, which have been shown to stimulate islet β-cell growth. Mutations in EXTL3 could lead to skeletal dysplasia, developmental delay, and severe immune deficiency (PMID: 28148688). The predicted molecular weight is 105 kDa, but we detected the band at 65 kDa perhaps due to alternative splicing (PMID: 14618397).