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FABP4 Monoklonaler Antikörper

FABP4 Monoklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

3E7E1

Kat-Nr. : 67167-1-PBS

Synonyme

A FABP, AFABP, ALBP, aP2, FABP4, Fatty acid binding protein 4

Filter:
  • Western Blot (WB) analysis of various lysates using FABP4 Monoclonal antibody (67167-1-Ig)

    WB analysis using 67167-1-Ig (same clone as 67167-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67167-1-Ig (FABP4 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67167-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using FABP4 Monoclonal antibody (67167-1-Ig)

    IHC staining of human breast cancer using 67167-1-Ig (same clone as 67167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 67167-1-Ig (FABP4 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67167-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67167-1-PBS bindet in WB, IHC, Indirect ELISA FABP4 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
Wirt / Isotyp Maus / IgG2b
Klonalität Monoklonal
Typ Antikörper
Immunogen FABP4 fusion protein Ag8565
Vollständiger Name fatty acid binding protein 4, adipocyte
Berechnetes Molekulargewicht 132 aa, 15 kDa
Beobachtetes Molekulargewicht 14 kDa
GenBank-ZugangsnummerBC003672
Gene symbol FABP4
Gene ID (NCBI) 2167
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Fatty acid binding protein (FABP) 4 is a member of the FABP family which abundantly expressed, fatty acid carrier proteins. FABPs are capable of binding a variety of hydrophobic molecules such as long-chain fatty acids and are important for their uptake and intracellular trafficking. It was first identified as an adipocyte-specific protein, important for the maintenance of lipid and glucose metabolism. It is also detected in macrophages, where it participates in regulating inflammation and cholesterol trafficking via NFκB and PPAR. In more recent studies, FABP4 has been found in a variety of endothelial cells, where it has been identified as a target of VEGF and a regulator of cell proliferation and possibly angiogenesis. Pathologically, FABP4 has been associated with the development of metabolic syndrome, diabetes and cancer and vulnerability of atherosclerotic plaques. FABP4 has been identified as a novel prognostic factor for both adverse cardiovascular events and breast cancer.