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FANCD2 Polyklonaler Antikörper

FANCD2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 28619-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using FANCD2 Polyclonal antibody (28619-1-AP)

    WB analysis using 28619-1-AP (same clone as 28619-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28619-1-AP (FANCD2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28619-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

28619-1-PBS bindet in WB, Indirect ELISA FANCD2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen FANCD2 fusion protein Ag29460
Vollständiger Name Fanconi anemia, complementation group D2
Berechnetes Molekulargewicht 164 kDa
Beobachtetes Molekulargewicht 150 kDa
GenBank-ZugangsnummerNM_001018115
Gene symbol FANCD2
Gene ID (NCBI) 2177
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FANCD2, also named as FACD and FACD2, is required for maintenance of chromosomal stability. FANCD2 promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. It may participate in S phase and G2 phase checkpoint activation upon DNA damage. It promotes BRCA2/FANCD1 loading onto damaged chromatin. FANCD2 may also be involved in B-cell immunoglobulin isotype switching. Defects in FANCD2 are a cause of Fanconi anemia (FA) which is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies.