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FANCL Monoklonaler Antikörper

FANCL Monoklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

6E2B6

Kat-Nr. : 66639-1-PBS

Synonyme

FAAP43, FANCL, Fanconi anemia group L protein, PHF9, POG

Filter:
  • Western Blot (WB) analysis of HeLa cells using FANCL Monoclonal antibody (66639-1-Ig)

    WB analysis of HeLa using 66639-1-Ig (same clone as 66639-1-PBS)

    HeLa cells and HEK-293 cells were subjected to SDS PAGE followed by western blot with 66639-1-Ig (FANCL antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66639-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HEK-293 cells using FANCL Monoclonal antibody (66639-1-Ig)

    WB analysis of HEK-293 using 66639-1-Ig (same clone as 66639-1-PBS)

    WB result of FANCL antibody (66639-1-Ig; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-FANCL transfected HEK-293 cells. This data was developed using the same antibody clone with 66639-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using FANCL Monoclonal antibody (66639-1-Ig)

    IF Staining of HeLa using 66639-1-Ig (same clone as 66639-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using FANCL antibody (66639-1-Ig, Clone: 6E2B6 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66639-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

66639-1-PBS bindet in WB, IF/ICC, Indirect ELISA FANCL und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen FANCL fusion protein Ag6192
Vollständiger Name Fanconi anemia, complementation group L
Berechnetes Molekulargewicht 43 kDa
Beobachtetes Molekulargewicht 41-43 kDa
GenBank-ZugangsnummerBC054517
Gene symbol FANCL
Gene ID (NCBI) 55120
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Fanconi anemia (FA) is a hereditary bone marrow failure syndrome associated with developmental defects and cancer predisposition. The FA nuclear core complex consists of FANCA, B, C, E, F, G, L, and M. FANCL is a RING-type E3 ubiquitin ligase that monoubiquitinates FANCD2 and FANCI, a key functional role facilitated by other members of the nuclear core complex (PMID: 23783032). FANCL plays an important role in the repair of cisplatin-induced DNA damage (PMID: 26385482) and participates directly in support of stem cell function (PMID: 23783032). FANCL can be detected as 40-43 kDa (full-length) and ~28 kDa.