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FAT2 Polyklonaler Antikörper

FAT2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31490-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using FAT2 Polyclonal antibody (31490-1-AP)

    WB analysis using 31490-1-AP (same clone as 31490-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31490-1-AP (FAT2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31490-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31490-1-PBS bindet in WB, Indirect ELISA FAT2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen FAT2 fusion protein Ag34942
Vollständiger Name FAT tumor suppressor homolog 2 (Drosophila)
Berechnetes Molekulargewicht479 kDa
Beobachtetes Molekulargewicht500-600 kDa
GenBank-ZugangsnummerNM_001447
Gene symbol FAT2
Gene ID (NCBI) 2196
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FAT2 (FAT atypical cadherin 2), also known as CDHF8. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level). The molecular weight of FAT2 is 473 kDa. The huge molecular masses (about 500-600 kDa) have hindered studies of the molecular aspects of itself roles(PMID: 15923647).