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FBX4 Polyklonaler Antikörper

FBX4 Polyklonal Antikörper für IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13855-1-PBS

Synonyme

FBXO4, F-box only protein 4, F box protein 4, F box only protein 4

Filter:
  • Immunoprecipitation (IP) experiment of HeLa cells using FBX4 Polyclonal antibody (13855-1-AP)

    IP experiment of HeLa using 13855-1-AP (same clone as 13855-1-PBS)

    IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with HeLa cells lysate 1400 ug. This data was developed using the same antibody clone with 13855-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of A431 cells using FBX4 Polyclonal antibody (13855-1-AP)

    IP experiment of A431 using 13855-1-AP (same clone as 13855-1-PBS)

    IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with A431 cells lysate 1040 ug. This data was developed using the same antibody clone with 13855-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

13855-1-PBS bindet in IP, Indirect ELISA FBX4 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen FBX4 fusion protein Ag4829
Vollständiger Name F-box protein 4
Berechnetes Molekulargewicht 44 kDa
Beobachtetes Molekulargewicht38 kDa
GenBank-ZugangsnummerBC048098
Gene symbol FBXO4/FBX4
Gene ID (NCBI) 26272
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FBX4 (F-Box Protein 4), also known as FBXO4, is a member of the F-box protein family. FBX4 is involved in the ubiquitination of various target proteins, leading to their degradation. It has been shown to regulate the cell cycle by targeting proteins such as cyclin D1 for ubiquitination and degradation. Mutations in FBX4 have been linked to various diseases, including spermatogenic failure and esophageal cancer. In cancer, FBX4 has been shown to act as a tumor suppressor. Loss of FBX4 function can lead to increased cell proliferation and tumor development. For example, FBX4 knockout mice have been shown to develop various tumors, including lymphoblastic lymphoma and mammary carcinoma.