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FBXL20 Polyklonaler Antikörper

FBXL20 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20949-1-PBS

Synonyme

Fbl2, Fbl20

Filter:
  • Western Blot (WB) analysis of various lysates using FBXL20 Polyclonal antibody (20949-1-AP)

    WB analysis using 20949-1-AP (same clone as 20949-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 20949-1-AP (FBXL20 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20949-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

20949-1-PBS bindet in WB, Indirect ELISA FBXL20 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen FBXL20 fusion protein Ag15071
Vollständiger Name F-box and leucine-rich repeat protein 20
Berechnetes Molekulargewicht 436 aa, 48 kDa
Beobachtetes Molekulargewicht48 kDa
GenBank-ZugangsnummerBC007557
Gene symbol FBXL20
Gene ID (NCBI) 84961
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FBXL20 (F-box and leucine-rich repeat protein 20) is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system. FBXL20 acts as a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex, targeting specific proteins for ubiquitination and subsequent degradation. This protein is involved in cell cycle regulation, signal transduction, and maintenance of protein homeostasis. Abnormal expression of FBXL20 has been implicated in various diseases, including cancer and neurodegenerative disorders. Research also suggests that FBXL20 may regulate the degradation of 4-1BB, an important immune stimulator, through ubiquitination. (PMID: 25593308, PMID: 27502938, PMID: 35112462)