FBXL6 Polyklonaler Antikörper

FBXL6 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33265-1-PBS

Synonyme

FBL6, FBL6A, F-box and leucine-rich repeat protein 6, F-box protein FBL6, F-box/LRR-repeat protein 6

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  WB analysis using 33265-1-AP (same clone as 33265-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33265-1-AP (FBXL6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33265-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

33265-1-PBS bindet in WB, Indirect ELISA FBXL6 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FBXL6 fusion protein Ag36604
• Vollständiger Name: F-box and leucine-rich repeat protein 6
• Berechnetes Molekulargewicht: 59kDa，539aa
• Beobachtetes Molekulargewicht: 60 kDa
• GenBank-Zugangsnummer: NM_012162.3
• Gene symbol: FBXL6
• Gene ID (NCBI): 26233
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FBXL6 is an F-box/LRR-type E3 ubiquitin ligase that serves as the substrate-recognition subunit of the SCF complex. It stabilizes HSP90AA1 via K63-linked ubiquitination to activate c-MYC and drive hepatocellular carcinoma progression, while also degrading defective mitochondrial ribosomal proteins to preserve mitochondrial proteostasis. Its overexpression correlates with poor prognosis in renal and colorectal cancers and can promote cell proliferation by down-regulating RPL11 to activate the MDM2-p53 axis.