FBXL8 Polyklonaler Antikörper

FBXL8 Polyklonal Antikörper für IHC, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

IHC, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16505-1-PBS

Synonyme

FBL8, F-box and leucine-rich repeat protein 8, F-box protein FBL8, F-box/LRR-repeat protein 8

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  IP experiment of HCT 116 using 16505-1-AP (same clone as 16505-1-PBS)

  IP result of anti-FBXL8 (IP:16505-1-AP, 4ug; Detection:16505-1-AP 1:500) with HCT 116 cells lysate 1920 ug. This data was developed using the same antibody clone with 16505-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 16505-1-AP (same clone as 16505-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 16505-1-AP (FBXL8 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16505-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 16505-1-AP (same clone as 16505-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 16505-1-AP (FBXL8 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16505-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

16505-1-PBS bindet in IHC, IP, Indirect ELISA FBXL8 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FBXL8 fusion protein Ag9685
• Vollständiger Name: F-box and leucine-rich repeat protein 8
• Berechnetes Molekulargewicht: 374 aa, 41 kDa
• Beobachtetes Molekulargewicht: 41 kDa
• GenBank-Zugangsnummer: BC014414
• Gene symbol: FBXL8
• Gene ID (NCBI): 55336
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FBXL8 is a conserved F-box protein that belongs to the ubiquitin ligase complex. It plays a significant role in various cellular processes, including tumorigenesis and metastasis. In colorectal cancer, FBXL8 promotes liver metastasis and stem-cell-like features by mediating ubiquitination and degradation of TP53. Additionally, FBXL8 has been shown to inhibit lymphoma growth and hematopoietic malignancies by targeting specific substrates for degradation. In the context of cardiac fibrosis, FBXL8 inhibits post-myocardial infarction cardiac fibrosis by regulating the ubiquitination of key proteins (PMID: 36855778, PMID: 33122824, PMID: 38615011).