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FBXO22 Monoklonaler Antikörper

FBXO22 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

4B8A12

Kat-Nr. : 68650-1-PBS

Synonyme

FBX22, F-box protein FBX22p44, F-box only protein 22, F box protein 22, F box only protein 22

Filter:
  • Western Blot (WB) analysis of Jurkat cells using FBXO22 Monoclonal antibody (68650-1-Ig)

    WB analysis of Jurkat using 68650-1-Ig (same clone as 68650-1-PBS)

    WB result of FBXO22 antibody (68650-1-Ig; 1:4000; room temperature for 1.5 hours) with wild-type and FBXO22 knockout Jurkat cells. This data was developed using the same antibody clone with 68650-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using FBXO22 Monoclonal antibody (68650-1-Ig)

    WB analysis using 68650-1-Ig (same clone as 68650-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68650-1-Ig (FBXO22 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68650-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68650-1-PBS bindet in WB, Indirect ELISA FBXO22 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen FBXO22 fusion protein Ag5294
Vollständiger Name F-box protein 22
Berechnetes Molekulargewicht 403 aa, 45 kDa
Beobachtetes Molekulargewicht45 kDa
GenBank-ZugangsnummerBC039024
Gene symbol FBXO22
Gene ID (NCBI) 26263
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FBXO22, also named as FBX22, is a substrate-recognition of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO22 is a key regulator of senescence induction through ubiquitylation of p53 for degradation. FBXO22 also acts as a molecular switch for the antagonistic and agonistic actions of selective estrogen receptor modulators (SERM) and determines the sensitivity of breast cancer to SERM by ubiquitylating KDM4B complexed with unliganded or SERMs‐bound estrogen receptor (ER). (PMID: 32536008, PMID: 32249768)