FBXO32 Polyklonaler Antikörper

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• KD/KO Validated

FBXO32 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte und mehr (3)

Anwendung

WB, IHC, IF, IP, ELISA

Konjugation

Unkonjugiert

Publikationen(22)

Kat-Nr. : 12866-1-AP

Synonyme

Atrogin 1, F box only protein 32, F box protein 32, Fbx32, FBXO32, MAFbx, Muscle atrophy F box protein

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  WB analysis of mouse skeletal muscle using 12866-1-AP

  mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12866-1-AP (FBXO32 Antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse skeletal muscle using 12866-1-AP

  mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12866-1-AP (FBXO32 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse heart using 12866-1-AP

  mouse heart tissue were subjected to SDS PAGE followed by western blot with 12866-1-AP (FBXO32 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 21 publications below
• IHC: See 1 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Produktinformation

12866-1-AP bindet in WB, IHC, IF, IP, ELISA FBXO32 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Eichh?rnchen, Hausschwein, Maus, Ratte, Zebrafisch
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FBXO32 fusion protein Ag3474
• Vollständiger Name: F-box protein 32
• Berechnetes Molekulargewicht: 355 aa, 42 kDa
• GenBank-Zugangsnummer: BC024030
• Gene symbol: FBXO32
• Gene ID (NCBI): 114907
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FBXO32 (F box only protein 32), also known as Atrogin 1 or MAFbx, is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif F-box. This protein is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. FBXO32 is thus a potential drug target for the treatment of muscle atrophy. Some data support that FBXO32 may play an important role in tumorigenesis. Recent study reveal that FBXO32 targets the oncogenic protein c-Myc for ubiquitination and degradation through the proteasome pathway.

Publikationen

Species	Application	Title
mouse	WB	J Cachexia Sarcopenia Muscle; Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.; Authors - Jie Dong
human	WB	Elife; The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy; Authors - Yurika Ito
mouse	WB	J Agric Food Chem; Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.; Authors - Luchu Zhang
mouse	WB	Aging (Albany NY); Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes.; Authors - Yehui Duan
mouse	WB,IHC	Oncotarget; PMID: 28489606; Authors - Dunwei Guo
zebrafish	WB	Nutrients; A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity.; Authors - Yun-Yi Zou