FBX4 Polyklonaler Antikörper

FBX4 Polyklonal Antikörper für IP, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IP, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13855-1-AP

Synonyme

FBXO4, F-box only protein 4, F box protein 4, F box only protein 4

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  IP experiment of HeLa using 13855-1-AP

  IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with HeLa cells lysate 1400 ug.

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  IP experiment of A431 using 13855-1-AP

  IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with A431 cells lysate 1040 ug.

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Geprüfte Anwendungen

• Erfolgreiche IP: HeLa-Zellen, A431-Zellen

Empfohlene Verdünnung

• Immunpräzipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

13855-1-AP bindet in IP, ELISA FBX4 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FBX4 fusion protein Ag4829
• Vollständiger Name: F-box protein 4
• Berechnetes Molekulargewicht: 44 kDa
• Beobachtetes Molekulargewicht: 38 kDa
• GenBank-Zugangsnummer: BC048098
• Gene symbol: FBXO4/FBX4
• Gene ID (NCBI): 26272
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FBX4 (F-Box Protein 4), also known as FBXO4, is a member of the F-box protein family. FBX4 is involved in the ubiquitination of various target proteins, leading to their degradation. It has been shown to regulate the cell cycle by targeting proteins such as cyclin D1 for ubiquitination and degradation. Mutations in FBX4 have been linked to various diseases, including spermatogenic failure and esophageal cancer. In cancer, FBX4 has been shown to act as a tumor suppressor. Loss of FBX4 function can lead to increased cell proliferation and tumor development. For example, FBX4 knockout mice have been shown to develop various tumors, including lymphoblastic lymphoma and mammary carcinoma.