FBXW8 Polyklonaler Antikörper

FBXW8 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33578-1-PBS

Synonyme

F-box and WD-40 domain-containing protein 8, F-box only protein 29, F-box/WD repeat-containing protein 8, FBW6, FBW8

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  WB analysis using 33578-1-AP (same clone as 33578-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33578-1-AP (FBXW8 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33578-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

33578-1-PBS bindet in WB, Indirect ELISA FBXW8 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FBXW8 fusion protein Ag36986
• Vollständiger Name: F-box and WD repeat domain containing 8
• Berechnetes Molekulargewicht: 67 kDa
• Beobachtetes Molekulargewicht: 67 kDa, 60 kDa
• GenBank-Zugangsnummer: BC037296
• Gene symbol: FBXW8
• Gene ID (NCBI): 26259
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Fbxw8 (also known as Fbw6 or Fbx29) is an F-box protein that is assembled with Cul7 in an SCF-like E3 complex. FBXW8 directs the proteasomal degradation of β-TrCP1 in MAPK pathway-dependent manner, and the attenuation of β-TrCP1 by FBXW8 is important for Cdc25A-mediated cell cycle transition from G1 phase to S phase as well as DNA damage-free progression of S phase (PMID: 33742524).