FCRL1 Rekombinanter Antikörper

FCRL1 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

251080E1

Kat-Nr. : 98557-1-RR

Synonyme

CD307a, Fc receptor-like protein 1, FcRH1, FcR-like protein 1, IFGP family protein 1

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  FC experiment of human PBMCs using 98557-1-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human FCRL1 Rabbit RecAb (98557-1-RR, Clone: 251080E1) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  FC experiment of human PBMCs using 98557-1-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human FCRL1 Rabbit RecAb (98557-1-RR, Clone: 251080E1) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  FC experiment of Transfected CHO using 98557-1-RR

  1x10^6 CHO Cells (left) or FCRL1(CD307a)-transfected CHO Cells (right) were surface stained with 0.25 ug Anti-Human FCRL1 Rabbit RecAb (98557-1-RR, Clone: 251080E1) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: humane PBMCs, Transfected CHO cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98557-1-RR bindet in FC FCRL1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: FCRL1 fusion protein Eg3713
• Vollständiger Name: Fc receptor-like 1
• Berechnetes Molekulargewicht: 429 aa, 47 kDa
• GenBank-Zugangsnummer: BC033690
• Gene symbol: FCRL1
• Gene ID (NCBI): 115350
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

Fc receptor-like protein 1 (FCRL1) is a type I transmembrane glycoprotein that plays a crucial role in regulating B-cell receptor (BCR)-mediated signaling responses (PMID:15479727). It contains intracellular tyrosine-based motifs that can modulate BCR signaling, leading to changes in calcium flux, proliferation, and antibody production (PMID: 37822931). FCRL1 is involved in regulating B-cell development and activation, with its signaling pathways influencing ERK activation through interactions with proteins such as GRB2. This regulation is essential for maintaining B-cell homeostasis and preventing the development of autoreactive B cells (PMID: 34697226).