FDPS Polyklonaler Antikörper

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• KD/KO Validated

FDPS Polyklonal Antikörper für IP, WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IP, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen

13

Kat-Nr. : 16129-1-AP

Synonyme

FDPS, FPP synthase, FPPS, FPS, KIAA1293

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Galerie der Validierungsdaten

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  WB analysis using 16129-1-AP

  HepG2 cells were subjected to SDS PAGE followed by western blot with 16129-1-AP (FDPS antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

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  WB analysis of A431 using 16129-1-AP

  WB result of FDPS antibody (16129-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-FDPS transfected A431 cells.

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  WB analysis of human cerebellum using 16129-1-AP

  human cerebellum tissue were subjected to SDS PAGE followed by western blot with 16129-1-AP (FDPS antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

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  WB analysis of rat liver using 16129-1-AP

  rat liver tissue were subjected to SDS PAGE followed by western blot with 16129-1-AP (FDPS antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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  IP experiment of mouse liver using 16129-1-AP

  IP Result of anti-FDPS (IP:16129-1-AP, 4ug; Detection:16129-1-AP 1:1000) with mouse liver tissue lysate 4000ug.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HepG2-Zellen, A431-Zellen, humanes Cerebellum-Gewebe, Rattenlebergewebe
• Erfolgreiche IP: Mauslebergewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:5000
• Immunpräzipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 13 publications below
• IHC: See 2 publications below

Produktinformation

16129-1-AP bindet in WB, IP, IHC, ELISA FDPS und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FDPS fusion protein Ag9115
• Vollständiger Name: farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
• Berechnetes Molekulargewicht: 419 aa, 48 kDa
• Beobachtetes Molekulargewicht: 39-41 kDa
• GenBank-Zugangsnummer: BC010004
• Gene symbol: FDPS
• Gene ID (NCBI): 2224
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FPPS (also known as FDPS) is a key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. The expression of FPPS was elevated in prostate tumor cell lines, indicating its potential role in prostate cancer progression.

Publikationen

Species	Application	Title
human	WB	Cell Metab; Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism; Authors - Xin Yang ; KD Validated
mouse	WB, IHC	Cardiovasc Res; Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.; Authors - Jian Yang
human	WB,IHC	EBioMedicine; Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.; Authors - Parthasarathy Seshacharyulu
	WB	J Biol Chem; Does Viperin Function as a Radical S-adenosyl-L-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?; Authors - Caitlyn Makins
mouse	WB	Front Pharmacol; Transcriptomic Analysis Reveals the Protective Effects of Empagliflozin on Lipid Metabolism in Nonalcoholic Fatty Liver Disease.; Authors - Yuting Ma
mouse	WB	Int J Biochem Cell Biol; Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.; Authors - Yang Jian J