FGFR2/CD332 Rekombinanter Antikörper

FGFR2/CD332 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241383D11

Kat-Nr. : 98244-1-PBS

Synonyme

FGFR2, CFD1, CEK3, CD332, BFR 1

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  FC experiment of Transfected HEK-293T using 98244-1-RR (same clone as 98244-1-PBS)

  1x10^6 HEK-293T cells or FGFR2/CD332 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody (98244-1-RR, Clone: 241383D11) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98244-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98244-1-RR (same clone as 98244-1-PBS)

  1x10^6 HEK-293T cells (left) or FGFR2/CD332 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody (98244-1-RR, Clone:241383D11) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98244-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98244-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98244-1-RR against Human FGFR2/CD332 were performed. The affinity constant is 1.69 nM.

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Geprüfte Anwendungen

Produktinformation

98244-1-PBS bindet in FC FGFR2/CD332 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: fibroblast growth factor receptor 2
• Berechnetes Molekulargewicht: 92kd
• GenBank-Zugangsnummer: NM_000141.4
• Gene symbol: FGFR2
• Gene ID (NCBI): 2263
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

FGFR2 (Fibroblast growth factor receptor 2), also known as CD332, is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration, and apoptosis. Ligand binding leads to the activation of several signaling pathways, such as RAS, MAPK1/ERK2, MAPK3/ERK1, and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.