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FGFR4 Monoklonaler Antikörper

FGFR4 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1A2B5

Kat-Nr. : 67800-1-PBS

Synonyme

CD334, FGFR 4, FGFR4, JTK2, TKF

Filter:
  • Western Blot (WB) analysis of various lysates using FGFR4 Monoclonal antibody (67800-1-Ig)

    WB analysis using 67800-1-Ig (same clone as 67800-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67800-1-Ig (FGFR4 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67800-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67800-1-PBS bindet in WB, Indirect ELISA FGFR4 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen FGFR4 fusion protein Ag17041
Vollständiger Name fibroblast growth factor receptor 4
Berechnetes Molekulargewicht 88 kDa
Beobachtetes Molekulargewicht100-110 kDa
GenBank-ZugangsnummerBC011847
Gene symbol FGFR4
Gene ID (NCBI) 2264
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID:10336501).