FGFR4 Rekombinanter Antikörper

FGFR4 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242713H4

Kat-Nr. : 98383-2-PBS

Synonyme

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

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  FC experiment of HepG2 using 98383-2-RR (same clone as 98383-2-PBS)

  1x10^6 HepG2 cells(left) or A431 cells (right) were surface stained with 0.25 ug Anti-Human FGFR4 Rabbit RecAb (98383-2-RR, Clone:242713H4) and PE-Conjugated Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11) (blue). Cells were not fixed. This data was developed using the same antibody clone with 98383-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98383-2-PBS bindet in FC FGFR4 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: fibroblast growth factor receptor 4
• Berechnetes Molekulargewicht: 88 kDa
• GenBank-Zugangsnummer: BC011847
• Gene symbol: FGFR4
• Gene ID (NCBI): 2264
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression (PMID:10336501).