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FKBP5 Rekombinanter Antikörper

FKBP5 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250798G2

Kat-Nr. : 86189-1-PBS

Synonyme

FKBP-51, 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associated immunophilin, AIG6, Androgen-regulated protein 6

Filter:
  • Western Blot (WB) analysis of various lysates using FKBP5 Recombinant monoclonal antibody (86189-1-RR)

    WB analysis using 86189-1-RR (same clone as 86189-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86189-1-RR (FKBP5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86189-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86189-1-RR

    Affinity and Kinetic Characterization of 86189-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86189-1-RR against Human FKBP5 were performed. The affinity constant is 4.32 nM.

Geprüfte Anwendungen

Produktinformation

86189-1-PBS bindet in WB, Indirect ELISA FKBP5 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen FKBP5 fusion protein Ag5337
Vollständiger Name FK506 binding protein 5
Berechnetes Molekulargewicht 457 aa, 51 kDa
Beobachtetes Molekulargewicht51 kDa
GenBank-ZugangsnummerBC042605
Gene symbol FKBP5
Gene ID (NCBI) 2289
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FKBP5, also known as FKBP51, belongs to the family of immunophilins, FK506 binding proteins (FKBPs). FKBP5 is a negative regulator of GR activity and plays a key role in the termination of the stress response by GRs. FKBP5 limits GR function by decreasing ligand-binding sensitivity, thereby delaying nuclear translocation and reducing GR-dependent transcriptional activity. The known functions of FKBP5 include the regulation of steroid hormone receptors, inhibiting apoptosis in cancer cells, promoting Akt1 dephosphorylation, and inhibiting the Akt1 pathways, to name a few. FKBP5 is widely expressed and the calculated molecular weight is 51 kDa (PMID: 21119664, PMID: 34077736, PMID: 37154033).