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FLT3/CD135 Rekombinanter Antikörper

FLT3/CD135 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241414F8

Kat-Nr. : 98106-1-PBS

Synonyme

FLT3, FLK2, FL cytokine receptor, Fetal liver kinase-2, EC:2.7.10.1

Filter:
  • Flow cytometry (FC) experiment of Reh cells using Anti-Human FLT3/CD135 Rabbit Recombinant Antibody (98106-1-RR)

    FC experiment of Reh using 98106-1-RR (same clone as 98106-1-PBS)

    1x10^6 Reh cells (left) or U-937 cells (right) were surface stained with 0.25 ug Anti-Human FLT3 Rabbit Recombinant Antibody (98106-1-RR, Clone:241414F8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98106-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98106-1-RR

    Affinity and Kinetic Characterization of 98106-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98106-1-RR against Human FLT3/CD135 were performed. The affinity constant is 1.25 nM.

Geprüfte Anwendungen

Produktinformation

98106-1-PBS bindet in FC FLT3/CD135 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name fms-related tyrosine kinase 3
Berechnetes Molekulargewicht 993 aa, 113 kDa
GenBank-ZugangsnummerBC036028
Gene symbol FLT3
Gene ID (NCBI) 2322
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

FLT3 (also known as CD135 or FLK2) is a tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. FLT3 was originally identified by its expression in hematopoietic stem/progenitor cells (PMID: 7507245). It is important for the normal development of hematopoietic stem/progenitor cells. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.