FOXP1 Polyklonaler Antikörper
FOXP1 Polyklonal Antikörper für ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus, Ratte
Anwendung
ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 18596-1-AP
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Produktinformation
18596-1-AP bindet in ELISA FOXP1 und zeigt Reaktivität mit human, Maus, Ratten
| Getestete Reaktivität | human, Maus, Ratte |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | FOXP1 fusion protein Ag13402 |
| Vollständiger Name | forkhead box P1 |
| Berechnetes Molekulargewicht | 114 aa, 12 kDa |
| GenBank-Zugangsnummer | BC005055 |
| Gene symbol | FOXP1 |
| Gene ID (NCBI) | 27086 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3. |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
FOXP1, also named as HSPC215, is a transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. It is essential transcriptional regulator of B cell developmen. A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. FOXP1 is implicated in the pathogenesis of DLBCL and MALT lymphomas, through the identification of recurrent chromosome translocations that upregulate its expression levels and the correlation between high-level FOXP1 expression and poor prognosis. On initial examination, these data seem contrary to findings from the study of FOXP1 in epithelial malignancies, which suggest that it may represent a tumor suppressor gene. Convincing evidence linking the loss of the FOXP1 N-terminus and malignancy has already been generated through the study of recurrent viral integration sites that generate avian nephroblastomas.(PMID:18077790) The antibody recognize 2 smaller 60-65kd isoforms in mouse Lung.
