FOXP2 Polyklonaler Antikörper

• Featured Product
• KD/KO Validated

FOXP2 Polyklonal Antikörper für WB, IP, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF, IP, CoIP, ELISA

Konjugation

Unkonjugiert

Publikationen(6)

Rezensionen (1)

Kat-Nr. : 20529-1-AP

Synonyme

CAG repeat protein 44, CAGH44, forkhead box P2, Forkhead box protein P2, TNRC10

---

• 

  WB analysis using 20529-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 20529-1-AP (FOXP2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 20529-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 20529-1-AP (FOXP2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

• 

  IP experiment of mouse spleen using 20529-1-AP

  IP result of anti-FOXP2 (IP:20529-1-AP, 4ug; Detection:20529-1-AP 1:500) with mouse spleen tissue lysate 4000ug.

---

Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HCT 116-Zellen, Maushirngewebe, Mauslungengewebe, Neuro-2a-Zellen, Rattenhirngewebe
• Erfolgreiche IP: Mausmilzgewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000
• Immunpräzipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 2 publications below
• IHC: See 4 publications below
• IF: See 2 publications below
• CoIP: See 1 publications below

Produktinformation

20529-1-AP bindet in WB, IHC, IF, IP, CoIP, ELISA FOXP2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: FOXP2 fusion protein Ag14391
• Vollständiger Name: forkhead box P2
• Berechnetes Molekulargewicht: 80 kDa
• Beobachtetes Molekulargewicht: 70-80 kDa
• GenBank-Zugangsnummer: BC018016
• Gene symbol: FOXP2
• Gene ID (NCBI): 93986
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FOXP2, Forkhead box protein P2, is associated with speech and language development (PMID: 24765219). FOXP2 is expressed in the brain, lungs, heart and gut. In the brain, it is widely expressed in sensory, limbic and motor structures(PMID: 10880297, PMID:15685218). Mutations in FOXP2 caused the severe speech and language disorder developmental verbal dyspraxia (PMID: 15877281). FOXP2 was detected 2 isoforms of 70 kDa and 80-82 kDa (PMID: 15056696, PMID: 29360038, PMID: 17999357).

Publikationen

Species	Application	Title
		Elife; FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch.; Authors - Zachary Daniel Burkett
human	WB	Mol Ther Nucleic Acids; circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways.; Authors - Qianru He
human	WB,IHC,IF,CoIP	J Cancer; Low expression of FOXP2 predicts poor survival and targets caspase-1 to inhibit cell pyroptosis in colorectal cancer.; Authors - Peng Liao ; KD Validated
rat	IHC	BMC Biol; GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion; Authors - Hao-Qi Wang
rat,human	IHC,IF	Commun Biol; FOXP2 overexpression upregulates LAMA4 expression and thereby alleviates preeclampsia by regulating trophoblast behavior; Authors - Sishi Liu
human	IHC	Cell Rep; The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses; Authors - Marianna Tolve

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.

---

FH

Reyes (Verified Customer) (10-18-2024)

FOXP2 (in green) worked marking my neurons (in red) in FFPE human brain tissue, although other tests to check the specificity of the layer need to be performed.

• Applications: Immunofluorescence
• Primary Antibody Dilution: 1:100
• Cell Tissue Type: Human Brain Cortex

FOXP2 Antibody Immunofluorescence validation (1:100 dilution) in Human Brain Cortex (Cat no:20529-1-AP)