Follistatin Polyklonaler Antikörper

Follistatin Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (2)

Anwendung

WB, IHC,ELISA

Konjugation

Unkonjugiert

Publikationen

4

Kat-Nr. : 10474-1-AP

Synonyme

Activin binding protein, follistatin, FS, FST

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Galerie der Validierungsdaten

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 1 publications below
• IHC: See 4 publications below

Produktinformation

10474-1-AP bindet in WB, IHC,ELISA Follistatin und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Follistatin fusion protein Ag0775
• Vollständiger Name: follistatin
• Berechnetes Molekulargewicht: 33 aa, 7 kDa
• GenBank-Zugangsnummer: BC004107
• Gene symbol: FST
• Gene ID (NCBI): 10468
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor11 , and myostatin. It binds activin A with high affinity and whose expression can be induced by activin A and several other pro-inflammatory cytokines. Activin A-follistatin complexes are biologically inactive and bind to cell surface heparan sulphate-containing proteoglycans for internalisation and degradation. It has also been found to play a significant role in the management of skeletal muscle size and mass. It also has important roles in early embryonic development, differentiation of ovarian granulosa cells, liver fibrosis and polycystic ovarian syndrome.

Publikationen

Species	Application	Title
mouse	IHC	Am J Pathol; Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia.; Authors - Shawn K Ahlfeld
mouse	WB,IHC	Mol Pharm; Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis.; Authors - Wang Guqi G
rat	IHC	Cell Commun Signal; Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.; Authors - Lin Chen
human	IHC	J Int Med Res; Expression of activin A and follistatin in glioblastoma and their effects on U87 in vitro.; Authors - Zhang D F DF