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FUS/TLS Polyklonaler Antikörper
FUS/TLS Polyklonal Antikörper für IF/ICC, FC (Intra)
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus, Ratte
Anwendung
IF/ICC, FC (Intra)
Konjugation
CoraLite®488 Fluorescent Dye
Kat-Nr. : CL488-11570
Synonyme
Geprüfte Anwendungen
| Erfolgreiche Detektion in IF/ICC | HepG2-Zellen, HeLa-Zellen | 
| Erfolgreiche Detektion in FC (Intra) | MCF-7-Zellen | 
Empfohlene Verdünnung
| Anwendung | Verdünnung | 
|---|---|
| Immunfluoreszenz (IF)/ICC | IF/ICC : 1:50-1:500 | 
| Durchflusszytometrie (FC) (INTRA) | FC (INTRA) : 0.20 ug per 10^6 cells in a 100 µl suspension | 
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Produktinformation
CL488-11570 bindet in IF/ICC, FC (Intra) FUS/TLS und zeigt Reaktivität mit human, Maus, Ratten
| Getestete Reaktivität | human, Maus, Ratte | 
| Wirt / Isotyp | Kaninchen / IgG | 
| Klonalität | Polyklonal | 
| Typ | Antikörper | 
| Immunogen | FUS/TLS fusion protein Ag2150 | 
| Vollständiger Name | fusion (involved in t(12;16) in malignant liposarcoma) | 
| Berechnetes Molekulargewicht | 75 kDa | 
| GenBank-Zugangsnummer | BC026062 | 
| Gene symbol | FUS/TLS | 
| Gene ID (NCBI) | 2521 | 
| Konjugation | CoraLite®488 Fluorescent Dye | 
| Excitation/Emission maxima wavelengths | 491 nm / 516 nm | 
| Form | Liquid | 
| Reinigungsmethode | Antigen-Affinitätsreinigung | 
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA | 
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. | 
Hintergrundinformationen
FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration[PMID: 22640227]. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U)[PMID: 22640227]. This antibody is a rabbit polyclonal antibody raised against an internal region of human FUS. This antibody is conjugated with CL488, Ex/Em 488 nm/515 nm.
Protokolle
| PRODUKTSPEZIFISCHE PROTOKOLLE | |
|---|---|
| IF protocol for CL488 FUS/TLS antibody CL488-11570 | Protokoll herunterladen | 
| STANDARD-PROTOKOLLE | |
|---|---|
| Klicken Sie hier, um unsere Standardprotokolle anzuzeigen | 



