Fas/CD95 Rekombinanter Antikörper

Fas/CD95 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241229C11

Kat-Nr. : 98135-1-PBS

Synonyme

Fas, CD95, TNFR6, APT1, APO 1

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  FC experiment of mouse thymocytes using 98135-1-RR (same clone as 98135-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse Fas/CD95 Rabbit Recombinant Antibody (98135-1-RR, Clone: 241229C11) or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse CD8a (53-6.7) (APC-65069, Clone: 53-6.7). Cells were not fixed. This data was developed using the same antibody clone with 98135-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse thymocytes using 98135-1-RR (same clone as 98135-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.25 ug Anti-Mouse Fas/CD95 Rabbit Recombinant Antibody (98135-1-RR, Clone: 241229C11) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98135-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98135-1-PBS bindet in FC Fas/CD95 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: FusionProtein
• Vollständiger Name: Fas (TNF receptor superfamily member 6)
• Berechnetes Molekulargewicht: 37kDa
• GenBank-Zugangsnummer: NM_007987.2
• Gene symbol: Fas/CD95
• Gene ID (NCBI): 14102
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.