Fas/CD95 Rekombinanter Antikörper

Fas/CD95 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

CoraLite® Plus 405 Fluorescent Dye

CloneNo.

240340E11

Kat-Nr. : CL405-98034

Synonyme

FAS, APT1, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, APO-1

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  FC experiment of human PBMCs using CL405-98034

  1x10^6 human PBMCs were surface stained with APC Anti-Human CD45RO, and 5 ul CoraLite® Plus 405 Anti-Human Fas/CD95 Rabbit Recombinant Antibody (CL405-98034, Clone:240340E11) (right), or Isotype Control (left). Cells were not fixed.

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  FC experiment of human PBMCs using CL405-98034

  1x10^6 human PBMCs were surface stained with 5 ul CoraLite® Plus 405 Anti-Human Fas/CD95 Rabbit Recombinant Antibody (CL405-98034, Clone:240340E11) (red), and Isotype Control (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: humane PBMCs

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

CL405-98034 bindet in FC Fas/CD95 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Fusionsprotein
• Vollständiger Name: Fas (TNF receptor superfamily, member 6)
• Berechnetes Molekulargewicht: 38 kDa
• GenBank-Zugangsnummer: NM_000043.6
• Gene symbol: Fas/CD95
• Gene ID (NCBI): 355
• Konjugation: CoraLite® Plus 405 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 399 nm / 422 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

FAS, also named as CD95, APO-1, APT1, FAS1 and TNFRSF6, is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily, can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.