FcRn Monoklonaler Antikörper

FcRn Monoklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2H4A5

Kat-Nr. : 67944-1-PBS

Synonyme

alpha chain, FCGRT, FCRN, Neonatal Fc receptor

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  WB analysis using 67944-1-Ig (same clone as 67944-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67944-1-Ig (FcRn antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 67944-1-Ig (FcRn antibody) at dilution of 1:10000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 67944-1-Ig (same clone as 67944-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 67944-1-Ig (FcRn antibody) at dilution of 1:10000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67944-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

67944-1-PBS bindet in WB, IHC, Indirect ELISA FcRn und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: FcRn fusion protein Ag31173
• Vollständiger Name: Fc fragment of IgG, receptor, transporter, alpha
• Berechnetes Molekulargewicht: 40 kDa
• Beobachtetes Molekulargewicht: 35-40 kDa
• GenBank-Zugangsnummer: BC008734
• Gene symbol: FcRn
• Gene ID (NCBI): 2217
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).