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FcRn-Specific Polyklonaler Antikörper

FcRn-Specific Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16190-1-PBS

Synonyme

FCGRT, Neonatal Fc receptor, FCRN

Filter:
  • Western Blot (WB) analysis of various lysates using FcRn-Specific Polyclonal antibody (16190-1-AP)

    WB analysis using 16190-1-AP (same clone as 16190-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16190-1-AP (FcRn-Specific antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human spleen tissue using FcRn-Specific Polyclonal antibody (16190-1-AP)

    IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human spleen tissue using FcRn-Specific Polyclonal antibody (16190-1-AP)

    IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human liver tissue using FcRn-Specific Polyclonal antibody (16190-1-AP)

    IHC staining of human liver using 16190-1-AP (same clone as 16190-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

16190-1-PBS bindet in WB, IHC, Indirect ELISA FcRn-Specific und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name Fc fragment of IgG, receptor, transporter, alpha
Berechnetes Molekulargewicht 40 kDa
Beobachtetes Molekulargewicht40 kDa
GenBank-ZugangsnummerNM_004107
Gene symbol FcRn
Gene ID (NCBI) 2217
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).