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Fetuin-A/AHSG Rekombinanter Antikörper

Fetuin-A/AHSG Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1E4

Kat-Nr. : 80793-1-PBS

Synonyme

AHSG, Fetuin-A, Alpha 2 Z globulin, alpha 2 HS glycoprotein, AHS

Filter:
  • Western Blot (WB) analysis of human plasma using Fetuin-A/AHSG Recombinant antibody (80793-1-RR)

    WB analysis of human plasma using 80793-1-RR (same clone as 80793-1-PBS)

    human plasma were subjected to SDS PAGE followed by western blot with 80793-1-RR (Fetuin-A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80793-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 80793-1-RR

    Affinity and Kinetic Characterization of 80793-1-RR

    Biolayer interferometry (BLl) kinetic assays of 80793-1-RR against Human AHSG were performed. The affinity constant is 5.52 nM.

Geprüfte Anwendungen

Produktinformation

80793-1-PBS bindet in WB, Indirect ELISA Fetuin-A/AHSG und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Fetuin-A/AHSG fusion protein Ag9853
Vollständiger Name alpha-2-HS-glycoprotein
Berechnetes Molekulargewicht 367 aa, 39 kDa
Beobachtetes Molekulargewicht58 kDa
GenBank-ZugangsnummerBC048198
Gene symbol Fetuin-A
Gene ID (NCBI) 197
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Fetuin-A, also named as Alpha2-HS glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is a highly expressed glycoprotein in various fetal tissues whereas it is mainly expressed by the liver in adults. Fetuin A, an extracellular inhibitor of transforming growth factor β, is a profibrogenic stimulus in liver disease. Circulating fetuin-A may be a beneficial serum biomarker in the detection of liver and vascular fibrosis progression in patients with non-alcoholic fatty liver disease. It is also involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuin-A exerts its effects on the cardiovascular system by two different mechanisms. On the one hand it inhibits ins signaling and induces ins resistance contributing to the onset of atherosclerosis and on the other hand it inhibits calcium deposition and protects from vascular calcification.