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Frataxin Rekombinanter Antikörper

Frataxin Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250761C8

Kat-Nr. : 86195-4-PBS

Synonyme

FXN, CyaY, d FXN, dFXN, EC:1.16.3.1

Filter:
  • Western Blot (WB) analysis of SW480 cells using Frataxin Recombinant antibody (86195-4-RR)

    WB analysis of SW480 using 86195-4-RR (same clone as 86195-4-PBS)

    SW480 cells were subjected to SDS PAGE followed by western blot with 86195-4-RR (Frataxin antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86195-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86195-4-PBS bindet in WB, Indirect ELISA Frataxin und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Frataxin fusion protein Eg4622
Vollständiger Name frataxin
Berechnetes Molekulargewicht23kDa
Beobachtetes Molekulargewicht 14-23 kDa
GenBank-ZugangsnummerNM_000144.5
Gene symbol FXN
Gene ID (NCBI) 2395
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Frataxin (FXN), also named as FRDA, X25, m81-FXN, d-FXN, m78-FXN and i-FXN, belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. FXN is expressed in the cytoplasm as a 210 amino acid (AA) precursor protein (pFXN; 23 KDa) that is translocated into mitochondria where it is processed by two consecutive steps into iFXN (FXN 42-210; 19 KDa) and finally mFXN (81-210; 14.2 KDa), which is functional. (PMID: 26704351, PMID: 26671574)