G-CSFR Rekombinanter Antikörper

G-CSFR Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250343C6

Kat-Nr. : 98503-2-PBS

Synonyme

CD114, Csf3r, Csfgr, G-CSF receptor, G-CSF-R

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  FC experiment of mouse bone marrow cells using 98503-2-RR (same clone as 98503-2-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse G-CSFR Rabbit RecAb (98503-2-RR, Clone: 250343C6) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with APC Anti-Mouse Ly-6G/Ly-6C (Gr-1). Cells were not fixed. This data was developed using the same antibody clone with 98503-2-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse bone marrow cells using 98503-2-RR (same clone as 98503-2-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse G-CSFR Rabbit RecAb (98503-2-RR, Clone: 250343C6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98503-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98503-2-PBS bindet in FC G-CSFR und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: G-CSFR fusion protein Eg2702
• Vollständiger Name: colony stimulating factor 3 receptor (granulocyte)
• Berechnetes Molekulargewicht: 93 kDa
• GenBank-Zugangsnummer: NM_007782.3
• Gene symbol: Csf3r
• Gene ID (NCBI): 12986
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

G-CSF-R, also named as CSF3R, CD114 and GCSFR is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. It is a 130 kD to 150 kD glycoprotein single chain receptor which binds and activated by GCSF. In addition it may function in some adhesion or recognition events at the cell surface. It has been classified as a member of the hematopoietic (cytokine) receptor family, cytokine receptor class I, or the gp 130 related cytokine receptor family (although it does not apparently bind to gp 130). GCSF receptors can be found on neutrophils, myeloid leukemia cells that respond to GCSF, bone marrow cells of neutrophilic granulocyte lineage, and on placental trophoblasts. In addition, a soluble form is also expressed. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.