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GALNT8 Polyklonaler Antikörper

GALNT8 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 24025-1-PBS

Synonyme

pp GaNTase 8, GALNAC T8

Filter:
  • Western Blot (WB) analysis of various lysates using GALNT8 Polyclonal antibody (24025-1-AP)

    WB analysis using 24025-1-AP (same clone as 24025-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24025-1-AP (GALNT8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24025-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using GALNT8 Polyclonal antibody (24025-1-AP)

    WB analysis using 24025-1-AP (same clone as 24025-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24025-1-AP (GALNT8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24025-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24025-1-PBS bindet in WB, Indirect ELISA GALNT8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen GALNT8 fusion protein Ag21185
Vollständiger Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
Berechnetes Molekulargewicht 637 aa, 73 kDa
Beobachtetes Molekulargewicht73 kDa, 95 kDa
GenBank-ZugangsnummerBC140889
Gene symbol GALNT8
Gene ID (NCBI) 26290
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GALNT8 (Probable polypeptide N-acetylgalactosaminyltransferase 8) is a member of the UDP-GalNAc polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) family, which initiates mucin-like O-linked protein glycosylation in the Golgi apparatus. The tissue distribution of GALNT8 is high in the heart, skeletal muscle, kidney and liver; moderate in the placenta, small intestine, leukocyte and lung; and weak in the brain, colon, thymus and spleen (PMID: 34576978). The overexpression of GALNT8 significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC. GALNT8 encodes a 637-amino-acid type-II membrane protein (GalNAc-T8). The detected molecular weight of GALNT8 (95 kDa) is much higher than the theoretical molecular weight (70 kDa) due to three N-GlcNAc sites (N85, N107 and N160) (PMID: 34743989, 34239555).