GALR2 Polyklonaler Antikörper

GALR2 Polyklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 29909-1-PBS

Synonyme

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  WB analysis using 29909-1-AP (same clone as 29909-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29909-1-AP (GALR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 29909-1-AP (same clone as 29909-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 29909-1-AP (GALR2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 29909-1-AP (same clone as 29909-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 29909-1-AP (GALR2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 29909-1-AP (same clone as 29909-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using GALR2 antibody (29909-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

29909-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA GALR2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: GALR2 fusion protein Ag31762
• Vollständiger Name: galanin receptor 2
• Berechnetes Molekulargewicht: 42KD
• Beobachtetes Molekulargewicht: 42-50 kDa
• GenBank-Zugangsnummer: NM_003857
• Gene symbol: GALR2
• Gene ID (NCBI): 8811
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Galanin receptor type 2 (GALR2) is a receptor for galanin, GALP, and the hormone SPX1 (PMID:24517231). It is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamo-pituitary axis. Activation of the GALR2 may protect the hippocampus from neuronal damage (PMID: 17263796). It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibits adenylyl cyclase. GALR2 has a calculated molecular weight of 42 kDa.