GATM Polyklonaler Antikörper

GATM Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12801-1-PBS

Synonyme

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  WB analysis of mouse kidney using 12801-1-AP (same clone as 12801-1-PBS)

  mouse kidney tissue were subjected to SDS PAGE followed by western blot with 12801-1-AP (GATM antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12801-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat kidney using 12801-1-AP (same clone as 12801-1-PBS)

  rat kidney tissue were subjected to SDS PAGE followed by western blot with 12801-1-AP (GATM Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12801-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat pancreas using 12801-1-AP (same clone as 12801-1-PBS)

  rat pancreas tissue were subjected to SDS PAGE followed by western blot with 12801-1-AP (GATM Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12801-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human kidney using 12801-1-AP (same clone as 12801-1-PBS)

  human kidney tissue were subjected to SDS PAGE followed by western blot with 12801-1-AP (GATM antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12801-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 12801-1-AP (same clone as 12801-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 12801-1-AP (GATM antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 12801-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

12801-1-PBS bindet in WB, IHC, Indirect ELISA GATM und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: GATM fusion protein Ag3754
• Vollständiger Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase)
• Berechnetes Molekulargewicht: 423 aa, 48 kDa
• Beobachtetes Molekulargewicht: 48 kDa
• GenBank-Zugangsnummer: BC004141
• Gene symbol: GATM
• Gene ID (NCBI): 2628
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GATM, also known as AGAT, produces ornithine and guanidinoacetate (GAA) from arginine and glycine, and is a key enzyme for creatine synthesis. GATM deficiency in early infancy causes neurodevelopmental delay. GATM is predominantly expressed in kidney and pancreas in adults. Decrease of GAMT proteins was observed in proximal tubule damage cases, which links GATM as a general marker for proximal tubule damage. Alternative splicing of GATM generates three isoforms with molecular weights between 44 kDa to 48 kDa.