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GCNT3 Polyklonaler Antikörper

GCNT3 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 17101-1-PBS

Synonyme

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, C2/4GnT, C2GnT mucin type, C2GnT-M, C2GnT-mucin type

Filter:
  • Western Blot (WB) analysis of various lysates using GCNT3 Polyclonal antibody (17101-1-AP)

    WB analysis using 17101-1-AP (same clone as 17101-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17101-1-AP (GCNT3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17101-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human stomach cancer tissue using GCNT3 Polyclonal antibody (17101-1-AP)

    IHC staining of human stomach cancer using 17101-1-AP (same clone as 17101-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 17101-1-AP (GCNT3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17101-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

17101-1-PBS bindet in WB, IHC, Indirect ELISA GCNT3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen GCNT3 fusion protein Ag10765
Vollständiger Name glucosaminyl (N-acetyl) transferase 3, mucin type
Berechnetes Molekulargewicht 438 aa, 51 kDa
Beobachtetes Molekulargewicht51 kDa
GenBank-ZugangsnummerBC017032
Gene symbol GCNT3
Gene ID (NCBI) 9245
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Mucin-type core 2 1,6-N-acetylglucosaminyltransferase enzyme (C2GnT-M), encoded by the GCNT3 gene, has been reported to be altered in tumours and to possess tumour suppressor properties.GCNT3 is markedly expressed in both lung cancer tissues and BRCA tissues, and high GCNT3 levels correlate with poorer outcomes in patients undergoing radiotherapy (PMID: 25466507, 39697709). Elevated levels of GCNT3 promoted cell growth, migration, cell cycle development, and invasion, in addition to EMT, while suppressing apoptosis (PMID: 38789846).