GCS1 Polyklonaler Antikörper

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GCS1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 17859-1-PBS

Synonyme

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  WB analysis using 17859-1-AP (same clone as 17859-1-PBS)

  mouse colon tissue were subjected to SDS PAGE followed by western blot with 17859-1-AP (GCS1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

• 

  WB analysis of COLO 320 using 17859-1-AP (same clone as 17859-1-PBS)

  COLO 320 cells were subjected to SDS PAGE followed by western blot with 17859-1-AP (GCS1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human small intestine using 17859-1-AP (same clone as 17859-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine using 17859-1-AP (GCS1 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human small intestine using 17859-1-AP (same clone as 17859-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine using 17859-1-AP (GCS1 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 17859-1-AP (same clone as 17859-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver using 17859-1-AP (GCS1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 17859-1-AP (same clone as 17859-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver using 17859-1-AP (GCS1 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human small intestine using 17859-1-AP (same clone as 17859-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine using 17859-1-AP (GCS1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human small intestine using 17859-1-AP (same clone as 17859-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine using 17859-1-AP (GCS1 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 17859-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

17859-1-PBS bindet in WB, IHC, Indirect ELISA GCS1 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: GCS1 fusion protein Ag12321
• Vollständiger Name: mannosyl-oligosaccharide glucosidase
• Berechnetes Molekulargewicht: 837 aa, 92 kDa
• Beobachtetes Molekulargewicht: 80-92 kDa
• GenBank-Zugangsnummer: BC028337
• Gene symbol: GCS1
• Gene ID (NCBI): 7841
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MOGS (Mannosyl-oligosaccharide glucosidase), also known as GCS1, is the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor (PMID: 38187061). The resulting Glc(2)-Man(9)-GlcNAc(2) intermediate is then further modified by glucosidase II and several ER- and Golgi-resident mannosidases and glycosyltransferases, finally yielding a complex array of glycan structures (PMID: 3896128). MOGS has two isoforms, and it is located in the lumen of the endoplasmic reticulum.