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GFRAL Polyklonaler Antikörper

GFRAL Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 28335-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using GFRAL Polyclonal antibody (28335-1-AP)

    WB analysis using 28335-1-AP (same clone as 28335-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28335-1-AP (GFRAL antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28335-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

28335-1-PBS bindet in WB, Indirect ELISA GFRAL und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen GFRAL fusion protein Ag28504
Vollständiger Name GDNF family receptor alpha like
Berechnetes Molekulargewicht 45 aa, 85 kDa
Beobachtetes Molekulargewicht 45-60 kDa
GenBank-ZugangsnummerNM_207410
Gene symbol GFRAL
Gene ID (NCBI) 389400
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GFRAL (GDNF family receptor alpha-like), also called C6orf144, is the brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PMID: 28846097, 28846098, 28846099, 28953886, 36630958). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PMID: 32661391). GFRAL is a single-pass membrane protein, and localizes to the plasma membrane. It is mainly expressed in the hindbrain, and its mainstream molecular weight is 45-60 kd.