GPR124 Polyklonaler Antikörper

GPR124 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20050-1-PBS

Synonyme

Tumor endothelial marker 5, TEM5, KIAA1531, G-protein coupled receptor 124, G protein coupled receptor 124

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  IHC staining of mouse small intestine using 20050-1-AP (same clone as 20050-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue slide using 20050-1-AP (GPR124 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20050-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse lung using 20050-1-AP (same clone as 20050-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 20050-1-AP (GPR124 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20050-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

20050-1-PBS bindet in IHC, Indirect ELISA GPR124 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: G protein-coupled receptor 124
• Berechnetes Molekulargewicht: 143 kDa
• GenBank-Zugangsnummer: NM_032777
• Gene symbol: GPR124
• Gene ID (NCBI): 25960
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GPR124, also named KIAA1531 and TEM5, belongs to the G-protein coupled receptor 2 family and LN-TM7 subfamily. GPR124 is an Orphan receptor. GPR124 is a Tumor endothelial marker (TEM) that is significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. GPR124 is a member of the adhesion family of G protein-coupled receptors and is localized on the surface of endothelial cells. GPR124 is a seven-pass transmembrane receptor, unlike TEM1, TEM7, and TEM8 which span the membrane once. Proteolytically processed soluble GPR124 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans. The antibody recognizes near the C-term of GPR124. The antibody can't recognize the isoform3 of GPR124.