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GPR146 Polyklonaler Antikörper

GPR146 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16334-1-PBS

Synonyme

Filter:
  • Immunohistochemistry (IHC) staining of mouse liver tissue using GPR146 Polyclonal antibody (16334-1-AP)

    IHC staining of mouse liver using 16334-1-AP (same clone as 16334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 16334-1-AP (GPR146 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16334-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse kidney tissue using GPR146 Polyclonal antibody (16334-1-AP)

    IHC staining of mouse kidney using 16334-1-AP (same clone as 16334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 16334-1-AP (GPR146 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16334-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

16334-1-PBS bindet in IHC, Indirect ELISA GPR146 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen GPR146 fusion protein Ag9456
Vollständiger Name G protein-coupled receptor 146
Berechnetes Molekulargewicht 333 aa, 37 kDa
GenBank-ZugangsnummerBC014241
Gene symbol GPR146
Gene ID (NCBI) 115330
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

As a member of GPCRs, GPR146 (G protein-coupled receptor 146) was initially discovered as a c-peptide signal body. GPR146 may act as a c peptide receptor to interact with proinsulin c-peptide to regulate insulin levels (PMID: 37926274). Mechanically, GPR146 induces hepatic sterol regulatory element binding protein 2 (SREBP2) via the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, consequently resulting in hepatic low-density lipoprotein (VLDL) secretion (PMID: 32491159).