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GPSM2 Rekombinanter Antikörper

GPSM2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250793G2

Kat-Nr. : 86175-1-PBS

Synonyme

G protein signaling modulator 2, G-protein-signaling modulator 2, LGN, Pins

Filter:
  • Western Blot (WB) analysis of various lysates using GPSM2 Recombinant monoclonal antibody (86175-1-RR)

    WB analysis using 86175-1-RR (same clone as 86175-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86175-1-RR (GPSM2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86175-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86175-1-RR

    Affinity and Kinetic Characterization of 86175-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86175-1-RR against Human GPSM2 were performed. The affinity constant is 0.967 nM.

Geprüfte Anwendungen

Produktinformation

86175-1-PBS bindet in WB, Indirect ELISA GPSM2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen GPSM2 fusion protein Ag25195
Vollständiger Name G-protein signaling modulator 2 (AGS3-like, C. elegans)
Berechnetes Molekulargewicht 75 kDa
Beobachtetes Molekulargewicht70-77 kDa
GenBank-ZugangsnummerBC027732
Gene symbol GPSM2
Gene ID (NCBI) 29899
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GPSM2 belongs to a family of proteins that modulate activation of G proteins. GPSM2 assists in the exchange of guanine nucleotides, and allows extracellular signals to be transmitted to cells via cell surface, and ultimately plays a key role in the activation of G-proteins. Therefore, GPSM2 is a critical factor for the stability of cell division. Some recent studies have shown that GPSM2 messenger RNA (mRNA) is overexpressed and plays a positive role in the development of certain tumors, such as liver cancer, pancreatic cancer, breast cancer. It also plays a role in neuroblast division and in the development of normal hearing. Mutations in GPSM2 are associated with autosomal recessive nonsyndromic deafness (DFNB82), which is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss.