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GSDMB Rekombinanter Antikörper

GSDMB Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250653H4

Kat-Nr. : 86148-1-PBS

Synonyme

gasdermin B, Gasdermin like protein, Gasdermin-B, Gasdermin-B, C-terminal, Gasdermin-B, N-terminal

Filter:
  • Western Blot (WB) analysis of various lysates using GSDMB Recombinant antibody (86148-1-RR)

    WB analysis using 86148-1-RR (same clone as 86148-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86148-1-RR (GSDMB antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86148-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86148-1-PBS bindet in WB, Indirect ELISA GSDMB und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name gasdermin B
Berechnetes Molekulargewicht 411 aa, 47 kDa
Beobachtetes Molekulargewicht 47 kDa
GenBank-ZugangsnummerBC025682
Gene symbol GSDMB
Gene ID (NCBI) 55876
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GSDMB (Gasdermin B) is a member of the gasdermin family of proteins, which are involved in the regulation of pyroptosis, a form of programmed cell death. GSDMB plays a crucial role in immune responses, particularly against viral respiratory infections. It has also been implicated in various inflammatory and autoimmune diseases, as well as in cancer progression. GSDMB is known for its ability to induce pyroptosis by forming pores in cell membranes, leading to the release of inflammatory cytokines such as IL-1β and IL-18. This process is critical for combating infections and modulating immune responses. GSDMB can be activated by granzyme A (GZMA), which is released from natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), leading to inflammatory cell death and influencing the tumor immune microenvironment. GSDMB also interacts with other signaling pathways, such as the ERK pathway, to regulate cell proliferation and death. (PMID: 40452932; 38066523; 36163066)