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HAPLN1 Rekombinanter Antikörper

HAPLN1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241588E9

Kat-Nr. : 84374-4-PBS

Synonyme

Proteoglycan link protein, CRTL1, CRT1, Cartilage-linking protein 1, Cartilage-link protein

Filter:
  • Western Blot (WB) analysis of various lysates using HAPLN1 Recombinant antibody (84374-4-RR)

    WB analysis using 84374-4-RR (same clone as 84374-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84374-4-RR (HAPLN1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84374-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84374-4-RR

    Affinity and Kinetic Characterization of 84374-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84374-4-RR against Human HAPLN1 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

84374-4-PBS bindet in WB, Indirect ELISA HAPLN1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen HAPLN1 fusion protein Ag25221
Vollständiger Name hyaluronan and proteoglycan link protein 1
Berechnetes Molekulargewicht 40 kDa
Beobachtetes Molekulargewicht40-45 kDa
GenBank-ZugangsnummerBC057808
Gene symbol HAPLN1
Gene ID (NCBI) 1404
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

HAPLN1 (hyaluronan and proteoglycan link protein 1), also known as CRTL1. It is expected to be located in the cytoplasm and extracellular, and the protein is mainly expressed in placenta and small intestine. The calculated molecular weight of HAPLN1 is 40 kDa. HAPLN1 binds to aggrecan on the hyaluronic chain, stabilizing the aggregates and thus increasing compression resistance and shock absorption. HAPLN1 also functions as a growth factor, up regulating aggrecan and type II collagen synthesis in cartilage. It seems to be an essential part of cartilage homeostasis and may also contribute to homeostasis in the disc tissue (PMID: 23537453). It is reported in the literature that it is a double band.(PMID: 26341258)