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HER2/ErbB2 Rekombinanter Antikörper

HER2/ErbB2 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241366E6

Kat-Nr. : 98153-1-PBS

Synonyme

Her2 / ErbB2, Her2, Erbb2, EC:2.7.10.1, CD340

Filter:
  • Flow cytometry (FC) experiment of NIH/3T3 cells using Anti-Mouse HER2/ErbB2 Rabbit Recombinant Antibody (98153-1-RR)

    FC experiment of NIH/3T3 using 98153-1-RR (same clone as 98153-1-PBS)

    1x10^6 NIH/3T3 cells were surface stained with 0.25 ug Anti-Mouse HER2/ErbB2 Rabbit Recombinant Antibody (98153-1-RR, Clone: 241366E6) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98153-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98153-1-RR

    Affinity and Kinetic Characterization of 98153-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98153-1-RR against Mouse HER2/ErbB2 were performed. The affinity constant is 1.50 nM.

Geprüfte Anwendungen

Produktinformation

98153-1-PBS bindet in FC HER2/ErbB2 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Fusionsprotein
Vollständiger Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Berechnetes Molekulargewicht139 kDa
GenBank-ZugangsnummerNM_001003817.1
Gene symbol Erbb2
Gene ID (NCBI) 13866
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

HER2, also known as ErbB2, Neu, and CD340, is a 185-kDa transmembrane glycoprotein member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand-binding domain and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.